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https://med.cuhk.edu.hk/press-releases/cuhk-study-sees-increasing-global-incidence-of-colorectal-cancer-among-younger-people
https://med.cuhk.edu.hk/press-releases/cuhk-study-sees-increasing-global-incidence-of-colorectal-cancer-among-younger-people

CUHK Study Sees Increasing Global Incidence of Colorectal Cancer Among Younger People

The latest research by The Chinese University of Hong Kong (CUHK) has revealed that the global incidence of colorectal cancer among younger individuals has been marked by a continual increase, after analysing the colorectal cancer data in over 100 million people from six countries and regions, including Hong Kong, Shanghai, Japan, the United Kingdom (UK), the United States (US) and Sweden. Researchers pointed out that the “young-shift” in the incidence of colorectal cancer may be linked to obesity. The team will do further study to investigate the risk factors. The findings were presented at the Digestive Disease Week (DDW) in the US last week. 

 

Colorectal cancer as the most common cancer in Hong Kong

Colorectal cancer is the most common cancer type in Hong Kong and can be classified into two types: colon cancer and rectal cancer. According to statistics from the Hong Kong Cancer Registry of the Hospital Authority, there were over 5,000 registered new cases of colorectal cancer and over 2,000 people died of the disease in 2015. Risks of colorectal cancer increase with age. The incidence of cases and mortalities locally is concentrated in the mass of the population that is above 65 years old. 

 

There has been substantial proof around the world that colorectal cancer screening can lower the incidence rate of the disease. In the US, asymptomatic individuals regularly undergo screening for colorectal cancer from the age of 50. The incidence for individuals above the age of 50 there has been on the decline in recent years, but there appears to be a rise for those aged 20 to 50 years.

 

A young-shift in colon cancer was noted in the US and HK

In order to find out if there is a global trend towards a “young-shift” in colorectal cancer incidence along the lines of the US, the gastroenterology team of the Faculty of Medicine and Professor Kelvin TSOI from the Stanley Ho Big Data Decision Analytics Research Centre at CUHK gathered data from the International Agency for Research on Cancer (IARC) under the World Health Organization (WHO). The team analysed the data of six selected developed countries and regions, include Hong Kong, Shanghai, Japan, UK, US and Sweden, and looked into their colorectal cancer incidence trend after the year of 1988.

 

Until 2007, close to 66,000 people in the six selected countries or regions were diagnosed with colorectal cancer. Researchers further studied and calculated the annual percentage change in colon and rectal cancer incidence in different age groups. Results showed both Hong Kong and the US appeared to have a “young-shift” in colon cancer (marked in grey in the table below) over this 20-year period, which means a rising incidence in younger individuals under the age of 55, corresponding to a decreasing incidence in older individuals aged 55 or above.  

 

Read details below:

 

Countries or regionsColon cancer patients age <55
annual percentage change
Colon cancer patients age ³55
annual percentage change
Hong Kong1.7%-1.3%
Shanghai3%-0.1%
Japan-1.3%0.4%
UK0.1%0.7%
US3.1%-4.2%
Sweden1%0.2%

  

Overall rectal cancer incidence went up in HK

All studied countries and regions except Japan, have seen an increase in the number of younger rectal cancer patients. While young-shift appeared in the US and Sweden, the figure went up for both age groups in Hong Kong.

 

Countries or regionsRectal cancer patients age <55
annual percentage change
Rectal cancer patients age ³55
annual percentage change
Hong Kong3.5%2.5%
Shanghai4.4%-2.3%
Japan-1.1%0.2%
UK2.0%-0.5%
US3.3%-3.4%
Sweden1.3%-0.3%

 

Research team proposed “young-shift” links with obesity

DDW is a leading annual world professional forum on gastroenterology, hepatology, and endoscopy and gastrointestinal surgery. Dr. Rashid LUI, a specialist in gastroenterology and the Clinical Tutor (honorary) of Department of Medicine and Therapeutics in Faculty of Medicine at CUHK who presented the study at DDW, remarked, “Obesity is a growing global issue, especially among the younger population in developed countries. It is linked to the change in gut microbiota. We believe that could be one of the factors in why more and more younger individuals are suffering from colorectal cancer.”  

 

Professor Joseph SUNG, Mok Hing Yiu Professor of Medicine, CUHK concluded, “Society should pay more attention to the shift towards colorectal cancer incidence in the younger population and develop appropriate public health measures to tackle the problem, so as to lower the medical burden. Our further studies are to identify risk factors leading to this young shift in the cancer burden. Early detection is the key to prevent progression.”

 

The latest research conducted by the gastroenterology team of the Faculty of Medicine and the Stanley Ho Big Data Decision Analytics Research Centre at CUHK revealed that the global incidence of colorectal cancer among younger individuals has been marked by a continual increase. Research team members include Professor Joseph SUNG (right), Mok Hing Yiu Professor of Medicine, and Dr. Rashid LUI, Clinical Tutor (honorary) of Department of Medicine and Therapeutics in Faculty of Medicine at CUHK.

The latest research conducted by the gastroenterology team of the Faculty of Medicine and the Stanley Ho Big Data Decision Analytics Research Centre at CUHK revealed that the global incidence of colorectal cancer among younger individuals has been marked by a continual increase. Research team members include Professor Joseph SUNG (right), Mok Hing Yiu Professor of Medicine, and Dr. Rashid LUI, Clinical Tutor (honorary) of Department of Medicine and Therapeutics in Faculty of Medicine at CUHK.

Professor Joseph SUNG pointed out that age, gender, smoking, obesity and family history are the five factors related to the risk of developing colorectal cancer. The research team will continue to look into the causes of the “young-shift” in colorectal cancer.

Professor Joseph SUNG pointed out that age, gender, smoking, obesity and family history are the five factors related to the risk of developing colorectal cancer. The research team will continue to look into the causes of the “young-shift” in colorectal cancer.

Dr Rashid LUI hopes the recent study can raise the public awareness of the shift towards colorectal cancer incidence in the younger population.

Dr Rashid LUI hopes the recent study can raise the public awareness of the shift towards colorectal cancer incidence in the younger population.

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Surgical advancement
CUHK Advocates Atrial Fibrillation Screening and Drug Education to Reduce Risk of Stroke among Elderly

CUHK Advocates Atrial Fibrillation Screening and Drug Education to Reduce Risk of Stroke among Elderly

Clinical service
Screening Reveals Over 50% Community-dwelling Population Aged 65 or above are Pre-frail

Screening Reveals Over 50% Community-dwelling Population Aged 65 or above are Pre-frail

Research
Risk of Diabetes Patients Having Depression Doubles That of the General Public CUHK Advocates Timely Assessment of Diabetes Patients’ Mental Health Conditions

Risk of Diabetes Patients Having Depression Doubles That of the General Public CUHK Advocates Timely Assessment of Diabetes Patients’ Mental Health Conditions

Research
The 7th Palliative Care Symposium for Health Care Workers in Chinese Population: ‘Palliative Care in the Community’

The 7th Palliative Care Symposium for Health Care Workers in Chinese Population: ‘Palliative Care in the Community’

Symposium
Radiotherapy to Head and Neck Raises Risk for Stroke CUHK Proved Effectiveness of Carotid Angioplasty and Stenting

Radiotherapy to Head and Neck Raises Risk for Stroke CUHK Proved Effectiveness of Carotid Angioplasty and Stenting

Research
CUHK Succeeded in Animal Study and Clinical Case of Percutaneous Nanoknife New Breakthrough in Cancer Treatment

CUHK Succeeded in Animal Study and Clinical Case of Percutaneous Nanoknife New Breakthrough in Cancer Treatment

Research
CUHK and PolyU Jointly Introduce TeleStroke for 24-hour Thrombolysis Service at Prince of Wales Hospital

CUHK and PolyU Jointly Introduce TeleStroke for 24-hour Thrombolysis Service at Prince of Wales Hospital

Clinical service
CUHK Releases Research Results on Employment Status of Hong Kong Chronic Kidney Disease (CKD) Dialysis Patients and Promotes Predialysis Education Programme for Mid to Late Stage CKD patients

CUHK Releases Research Results on Employment Status of Hong Kong Chronic Kidney Disease (CKD) Dialysis Patients and Promotes Predialysis Education Programme for Mid to Late Stage CKD patients

Research
CUHK Announces Latest Medical Treatment for Minor Stroke

CUHK Announces Latest Medical Treatment for Minor Stroke

Research
CUHK-HCC Score Accurately Predicts Risk of Liver Cancer in Chronic Hepatitis B Patients Receiving Antiviral Therapy

CUHK-HCC Score Accurately Predicts Risk of Liver Cancer in Chronic Hepatitis B Patients Receiving Antiviral Therapy

Research
CUHK Received Four Ministry of Education Higher Education Outstanding Scientific Research Output Awards The Highest Share among Hong Kong Institutions

CUHK Received Four Ministry of Education Higher Education Outstanding Scientific Research Output Awards The Highest Share among Hong Kong Institutions

Awards and honors
CUHK and Shanghai Jiao Tong University Discover Genetic Predictor of Diabetes in Chinese Patients

CUHK and Shanghai Jiao Tong University Discover Genetic Predictor of Diabetes in Chinese Patients

Research
CUHK Pioneers the Use of 3D Echocardiography to Identify At-Risk Mitral Valve Prolapse Patients

CUHK Pioneers the Use of 3D Echocardiography to Identify At-Risk Mitral Valve Prolapse Patients

Research
CUHK will hold 'SARS A Decade On: A Conference for the Health Professionals'

CUHK will hold 'SARS A Decade On: A Conference for the Health Professionals'

Symposium
CUHK Advocates Palliative Care for Advanced Dementia Patients with Swallowing Problems

CUHK Advocates Palliative Care for Advanced Dementia Patients with Swallowing Problems

Research
CUHK Discovers Innovative ‘Flow Diverters’ (Pipeline) as Effective Treatment for Cerebral Aneurysms in Asia’s First Clinical Study in Collaboration with Seven Medical Centres

CUHK Discovers Innovative ‘Flow Diverters’ (Pipeline) as Effective Treatment for Cerebral Aneurysms in Asia’s First Clinical Study in Collaboration with Seven Medical Centres

Research
CUHK and HKU Host the 5th Annual Palliative Care Symposium for Health Care Workers in Chinese Population

CUHK and HKU Host the 5th Annual Palliative Care Symposium for Health Care Workers in Chinese Population

Symposium
CUHK Pioneers Innovative Computer Assisted Tumor Surgery for Bone Cancer Patients

CUHK Pioneers Innovative Computer Assisted Tumor Surgery for Bone Cancer Patients

Surgical advancement
CUHK Study Reveals High Salt Intake Will Lead to High Blood Pressure and Higher Risk of Stroke

CUHK Study Reveals High Salt Intake Will Lead to High Blood Pressure and Higher Risk of Stroke

Research
CUHK Launches Territory-wide Sleep Health Education Campaign to Promote Healthy Sleep and Healthy School Life

CUHK Launches Territory-wide Sleep Health Education Campaign to Promote Healthy Sleep and Healthy School Life

Health Campaign
CUHK and HKU's Collaborative Research Discovers Novel Epilepsy Genetic Markers

CUHK and HKU's Collaborative Research Discovers Novel Epilepsy Genetic Markers

Research
CUHK Advocates Early Detection of Chronic Kidney Diseases Joined by Leading Nephrologists to Make Sound Recommendations

CUHK Advocates Early Detection of Chronic Kidney Diseases Joined by Leading Nephrologists to Make Sound Recommendations

Research
CUHK Discovers Up to 30% of Asymptomatic Subjects in Hong Kong Suffered from Pre-cancerous Bowel Tumors

CUHK Discovers Up to 30% of Asymptomatic Subjects in Hong Kong Suffered from Pre-cancerous Bowel Tumors

Research
The Chinese University of Hong Kong Nethersole School of Nursing hosts the Fifth Pan-Pacific Nursing Conference and Seventh Nursing Symposium on Cancer Care

The Chinese University of Hong Kong Nethersole School of Nursing hosts the Fifth Pan-Pacific Nursing Conference and Seventh Nursing Symposium on Cancer Care

Symposium
CUHK Discovers High Prevalence of Colorectal Polyps among Fatty Liver Patients

CUHK Discovers High Prevalence of Colorectal Polyps among Fatty Liver Patients

Research
Why is Liver Cancer More Prevalent in Men than in Women? CUHK Discovers a Sex Hormone-controlled Gene that Promotes Liver Cancer

Why is Liver Cancer More Prevalent in Men than in Women? CUHK Discovers a Sex Hormone-controlled Gene that Promotes Liver Cancer

Research
CUHK Proves the Potent Efficacy of Stenting for Carotid Artery Narrowing and Cardiac Contractility Modulation for Heart Failure

CUHK Proves the Potent Efficacy of Stenting for Carotid Artery Narrowing and Cardiac Contractility Modulation for Heart Failure

Research
Three CUHK Scholars Named Croucher Senior Research Fellow 2011-12

Three CUHK Scholars Named Croucher Senior Research Fellow 2011-12

Awards and honors
CUHK Research Findings on Severe Human Swine Flu in Hong Kong

CUHK Research Findings on Severe Human Swine Flu in Hong Kong

Research

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